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Rowland Talent Solutions
oxfordshire, england, United Kingdom
We are currently recruiting for a Senior Scientist – Assay Development for a Biotechnology company based in Oxfordshire. As a Senior Scientist you will use your expertise in developing assay to support the company’s therapeutic development programme. Responsibilities include: Design and develop novel assays (immunoassay and ligand binding assays
Job Source: Rowland Talent SolutionsPLANET RECRUITMENT SERVICES LTD
United Kingdom
Job Title: Senior Scientist: Assay Development Location: Culham Science Park, Oxford Contract type: Permanent Salary: £40,000 -£60,000 Benefits: Excellent salary Free medical insurance Stock options within the company We are excited to be working with an innovative, and industry leading biotechnology company, based in Oxford, in a brand new, state-
Job Source: PLANET RECRUITMENT SERVICES LTDAkrivia Health
Oxford, England, United Kingdom
We are hiring a Senior AI Scientist to support the company in delivering its mission of improving the lives of patients by transforming research into mental illness and dementia. The company is working in this highly innovative area to accelerate the development of new treatments, improve healthcare services, and advance our understanding of comple
Job Source: Akrivia HealthMoa Technology
oxfordshire, england, United Kingdom
COMPANY PROFILE moa Technology Limited is an innovative and rapidly growing R&D crop protection company. At moa Technology our mission is to find the new generation of safe and effective herbicides to help farmers produce high quality food for all. To this aim, we have assembled a team of passionate and talented scientists, technician, and operatio
Job Source: Moa TechnologyRowland Talent Solutions limited
Oxfordshire
We are currently recruiting for a Senior Scientist - Assay Development for a Biotechnology company based in Oxfordshire. As a Senior Scientist you will use your expertise in developing assay to support the company's therapeutic development programme. Responsibilities include: Design and develop novel assays (immunoassay and ligand binding assays
Job Source: Rowland Talent Solutions limitedRowland Talent Solutions Limited
United Kingdom
We are currently recruiting for a Senior Scientist - Assay Development for a Biotechnology company based in Oxfordshire. As a Senior Scientist you will use your expertise in developing assay to support the company's therapeutic development programme. Responsibilities include: Design and develop novel assays (immunoassay and ligand binding assays)
Job Source: Rowland Talent Solutions LimitedNorthreach
oxfordshire, england, United Kingdom
Northreach is a dynamic recruitment agency that connects businesses with top talent in the Advanced therapy, fintech, and digital sectors. Our mission is to provide a seamless and personalised recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and professional growth.
Job Source: NorthreachNorthreach
oxfordshire, england, United Kingdom
Northreach is a dynamic talent solutions specialist that connects businesses with top talent in the cell & gene therapy, fintech, and digital sectors. Our mission is to provide a seamless and personalised recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and profession
Job Source: Northreachoxfordshire, england, United Kingdom
We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Protein Engineers with Phage Display expertise across varying levels of seniority to join their team.
This role is full-time and requires on-site presence for five days a week.
Role Summary
In this role you will be a core part of the Protein Engineering team, working collaboratively with other protein engineers and biochemists to develop soluble high affinity bispecific TCR molecules suitable for later stage clinical development.
Key Deliverables
Test, screen and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches.
Will include: (a) develop and undertake established and novel strategies to affinity mature candidate soluble TCRs; (b) design and construction of affinity maturation TCR libraries (c) Screening of affinity maturation libraries outputs for affinity and cross reactivity; (d) DNA recombinant subcloning (e) sequence analyses of the library outputs.
Collaboratively with the Biology and CMC teams to guide optimisation and development of soluble TCRs.
Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
Work to your department, project team and the company leadership team.
Collaboratively with the other teams to guide optimisation and development of soluble TCRs.
Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
Scientific findings and summary conclusions to your department, project team and the company leadership team.
Drive innovation and continuous improvement within the Protein Engineering team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process;
Experience & Qualifications Required
Provide oversight of specific elements within a project or projects and supervise other scientists.
A PhD in a relevant biological subject alongside some postdoctoral experience and/or experience in the biotech/pharma industry.
(Desired but not essential) Experience line managing/supervising other scientists.
(Desired but not essential) Experience working in a matrix environment.
Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules using molecular evolution approach (phage display, yeast display etc.
Strong proven expertise in molecular biology and protein engineering techniques, including rational design, phage display, library construction, affinity maturation approaches, site directed mutagenesis, cloning.
Experience in screening affinity maturation outputs and candidate molecules through techniques such as ELISA, DNA sequence analyses etc.
(Desired but not essential) Experience in purifying and refolding proteins.
(Desired but not essential) Experience in analyses of protein affinity and cross-reactivity using SPR/Biacore.
Working proactively with the team to develop effective strategies prioritised to the needs of the Protein Engineering group; collaborating effectively with other functions.
Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
Strong communication skills with the confidence and judgement to challenge appropriately.
Demonstrable problem- solving ability, creative thinking and be pro-active in driving the project forwards;
Protein Engineer (Scientist, Senior Scientist, Principal Scientist) jobs in oxfordshire, england, United Kingdom
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